Thats the kind of thing thats hard to beat
In the various three or more coloured versions of UG control decks I would always chose to play a Negate over an Actual Counterspell, those kinds of deck have an unrivalled ability to deal with permanents while coloured mana is more of an issue
Mega-Mega Cycles, on the other hand, have cycles that are completed in a completely different block to the one they started in, which means they can still happen (and do more often now that every set is considered its own block)
I was able to clean up the table after a few rounds with this final board state: Angel of Jubilation - just an anthem and would've shut down my fetches but I played it late game Linvala, Keeper of Silence - didn't stop anything on my opponent's board because they were all triggered abilities Starting hand was top heavy but decided to keep: Plains, Nykthos, Shrine to Nyx, Pearl Medallion, Sword of Hearth and Home, Well of Lost Dreams, Sword of the Animist, Archangel of Thune I figured with 2 ramp equipments and lifegain comboed with the well I'd be setup for mid-game pretty nicely
Key mechanics: Delve, graveyard matters, counters, discard, cost reduction, and recursion effects