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Loxi: Whew, this has the potential to ramp you a lot if you play enough creatures to make sure you can attack reliably with this

These effects are always hot commodities especially in Commander and this cards Visions printing is one of only three that this unusual and powerful enchantment has received

You touch on it in your last point, that there are different cases of feel-bad: board wipes, lockdown/hand hate and random luck/cascades are all different causes, but the biggest common factor in feeling bad is that you lose

Titania, Protector of Argoth is another good creature to have out ahead of time

Its the type of commander that you can get out early and likely wont be removed right away, so it can probably do a decent amount of damage